A Fine Art Photograph of the Junction 50 Sign with American Flag. This particular part of Interstate 50 is known as the 'Loneliest Highway in the World.' There are stretches through Nevada that there is literally nothing, not even, sometimes, another car. Gassing up before this drive is a must or you might find yourself waiting for days for Triple A to show up. Interstate 50 begins in Sacramento, California and winds its way through all of Nevada and Utah. On the Utah, Colorado border it becomes Interstate 70.